G0138 Intravenous cipaglucosidase alfa-atga
Also known as: IV Ambreya, enzyme replacement therapy
Intravenous infusion of cipaglucosidase alfa-atgamrasidase (Ambreya), an enzyme replacement therapy for Pompe disease, including preparation and administration.
In Plain Language
Intravenous enzyme medication for muscle disease; Pompe disease treatment infusion
Clinical Context
Specialized enzyme replacement therapy for Pompe disease (glycogen storage disease Type II). Administered as IV infusion; requires rheumatology or neurology specialist oversight.
RVU Breakdown
| Work RVU | 0.21 |
| Total RVU | 0.21 |
Est. Medicare Payment
National estimate based on 2026 CMS PFS Conversion Factor ($33.40). Actual payment varies by locality (GPCI adjustment).
Billing & Documentation
G-codes are CMS-specific HCPCS codes for services not covered by standard CPT. Documentation requirements follow the same standards as the equivalent CPT service. Check Medicare LCD/NCD policies for coverage criteria.
How This Code Compares
With a work RVU of 0.21, this code ranks in the 14th percentile among G Codes codes — 4.6x below the median (0.97). The highest wRVU in this category is 20.41.
Specialties
Frequently Asked Questions
What is CPT code G0138?
CPT G0138 (Intravenous cipaglucosidase alfa-atga) is a G Codes code. Intravenous infusion of cipaglucosidase alfa-atgamrasidase (Ambreya), an enzyme replacement therapy for Pompe disease, including preparation and administration.
Who uses CPT code G0138?
CPT G0138 is used by Internal Medicine, Neurology, Rare Disease. Specialized enzyme replacement therapy for Pompe disease (glycogen storage disease Type II). Administered as IV infusion; requires rheumatology or neurology specialist oversight.
When is CPT G0138 used?
Specialized enzyme replacement therapy for Pompe disease (glycogen storage disease Type II). Administered as IV infusion; requires rheumatology or neurology specialist oversight.
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CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.