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J1454 Injection fosnetupitant, palonoset

J Codes (Drugs)

Also known as: fosnetupitant/palonosetron, Akynzeo, dual antiemetic

Fosnetupitant and palonosetron combination injection. A dual antiemetic agent combining NK-1 antagonist and 5-HT3 antagonist for CINV prevention.

In Plain Language

combination nausea prevention; chemotherapy side effect treatment

Clinical Context

Used for acute and delayed chemotherapy-induced nausea and vomiting in highly emetogenic chemotherapy. Combination therapy addressing multiple nausea pathways.

RVU Information

CPT J1454 does not have a physician work RVU assigned by CMS. This is typical for supply, drug, and equipment codes — reimbursement is based on Average Sales Price (ASP), fee schedules, or payer contracts rather than the RVU system.

Billing & Documentation

J-codes represent drugs administered by a healthcare provider (not self-administered). Documentation must include the drug name, dosage, route of administration, and medical necessity. Most payers require the National Drug Code (NDC) on the claim. Bill the appropriate administration code (96365-96379) in addition to the drug code.

Specialties

OncologyInternal MedicineGastroenterology

Frequently Asked Questions

What is CPT code J1454?

CPT J1454 (Injection fosnetupitant, palonoset) is a J Codes (Drugs) code. Fosnetupitant and palonosetron combination injection. A dual antiemetic agent combining NK-1 antagonist and 5-HT3 antagonist for CINV prevention.

How is J1454 administered?

CPT J1454 is administered by a healthcare provider, typically via injection or infusion. Used for acute and delayed chemotherapy-induced nausea and vomiting in highly emetogenic chemotherapy. Combination therapy addressing multiple nausea pathways. It is used by Oncology, Internal Medicine, Gastroenterology.

When is CPT J1454 used?

Used for acute and delayed chemotherapy-induced nausea and vomiting in highly emetogenic chemotherapy. Combination therapy addressing multiple nausea pathways.

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CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.