81291 Mthfr gene
Also known as: MTHFR polymorphism test, MTHFR C677T testing
Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphism analysis to assess variants affecting folate metabolism and thrombotic risk.
In Plain Language
Folate metabolism genetic test; Blood clot risk genetic marker
Clinical Context
Identifies MTHFR variants that may affect folate metabolism and thrombotic risk. Clinical utility remains controversial but used in some specialty practices.
RVU Information
CPT 81291 does not have a physician work RVU assigned by CMS. Reimbursement for this code is determined by payer-specific fee schedules.
Billing & Documentation
Lab and pathology codes require an order from the treating provider with clinical indication. For molecular pathology and genetic testing, document the specific analytes tested and clinical rationale.
How This Code Compares
This code has a work RVU of 0.00, meaning it does not have a physician work component assigned by CMS. In the Pathology & Lab category, 94% of codes share this characteristic.
Specialties
Frequently Asked Questions
What is CPT code 81291?
CPT 81291 (Mthfr gene) is a Pathology & Lab code. Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphism analysis to assess variants affecting folate metabolism and thrombotic risk.
Who uses CPT code 81291?
CPT 81291 is used by Pathology, Genetics, Hematology. Identifies MTHFR variants that may affect folate metabolism and thrombotic risk. Clinical utility remains controversial but used in some specialty practices.
When is CPT 81291 used?
Identifies MTHFR variants that may affect folate metabolism and thrombotic risk. Clinical utility remains controversial but used in some specialty practices.
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CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.