Home
Career Stage
Medical Students Residents Attendings CPT Codes Resources Blog Support

81297 Msh2 gene dup/delete variant

Pathology & Lab

Also known as: MSH2 copy number analysis, MSH2 deletion duplication testing

Mutator S Homolog 2 (MSH2) gene duplication and deletion variant analysis to detect copy number variations in Lynch syndrome.

In Plain Language

MSH2 gene copy number test; Lynch syndrome copy variation detection

Clinical Context

Identifies MSH2 deletions and duplications to improve diagnostic yield in suspected Lynch syndrome when sequencing is negative.

RVU Information

CPT 81297 does not have a physician work RVU assigned by CMS. Reimbursement for this code is determined by payer-specific fee schedules.

Billing & Documentation

Lab and pathology codes require an order from the treating provider with clinical indication. For molecular pathology and genetic testing, document the specific analytes tested and clinical rationale.

How This Code Compares

This code has a work RVU of 0.00, meaning it does not have a physician work component assigned by CMS. In the Pathology & Lab category, 94% of codes share this characteristic.

Specialties

PathologyOncologyGastroenterology

Frequently Asked Questions

What is CPT code 81297?

CPT 81297 (Msh2 gene dup/delete variant) is a Pathology & Lab code. Mutator S Homolog 2 (MSH2) gene duplication and deletion variant analysis to detect copy number variations in Lynch syndrome.

Who uses CPT code 81297?

CPT 81297 is used by Pathology, Oncology, Gastroenterology. Identifies MSH2 deletions and duplications to improve diagnostic yield in suspected Lynch syndrome when sequencing is negative.

When is CPT 81297 used?

Identifies MSH2 deletions and duplications to improve diagnostic yield in suspected Lynch syndrome when sequencing is negative.

Track This Code in RVU Edge

Log procedures, calculate wRVUs, and benchmark against national data — all in one app.

CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.