88319 Enzyme histochemistry
Also known as: enzyme histochemistry, enzyme stain, enzymatic staining
Enzyme histochemical or cytochemical staining procedure to identify and localize specific enzyme activity within tissues.
In Plain Language
enzyme detection stain; enzyme activity staining
Clinical Context
Used to detect and visualize specific enzyme activities within tissues, useful for neuromuscular, metabolic, and other pathologic assessments.
RVU Breakdown
| Work RVU | 0.52 |
| Total RVU | 0.52 |
Est. Medicare Payment
National estimate based on 2026 CMS PFS Conversion Factor ($33.40). Actual payment varies by locality (GPCI adjustment).
Billing & Documentation
Lab and pathology codes require an order from the treating provider with clinical indication. For molecular pathology and genetic testing, document the specific analytes tested and clinical rationale.
How This Code Compares
With a work RVU of 0.52, this code ranks in the 39th percentile among Pathology & Lab codes — 1.3x below the median (0.68). The highest wRVU in this category is 2.78.
Specialties
Frequently Asked Questions
What is CPT code 88319?
CPT 88319 (Enzyme histochemistry) is a Pathology & Lab code. Enzyme histochemical or cytochemical staining procedure to identify and localize specific enzyme activity within tissues.
Who uses CPT code 88319?
CPT 88319 is used by Pathology, Neuropathology. Used to detect and visualize specific enzyme activities within tissues, useful for neuromuscular, metabolic, and other pathologic assessments.
When is CPT 88319 used?
Used to detect and visualize specific enzyme activities within tissues, useful for neuromuscular, metabolic, and other pathologic assessments.
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CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.