45385 Colonoscopy with lesion removal
Also known as: colonoscopy with large polyp removal, colon advanced polypectomy, colonoscopy with polypectomy snare, snare polypectomy, colonoscopy with polypectomy, colonoscopy polypectomy, polyp removal colonoscopy
Colonoscopy with removal of large polyp(s) requiring advanced polypectomy technique.
In Plain Language
removal of large polyps from colon; complex polyp resection
Clinical Context
Performed for large sessile polyps requiring piece-meal resection, endoscopic mucosal resection, or endoscopic submucosal dissection.
RVU Breakdown
| Work RVU | 4.46 |
| Total RVU | 4.46 |
Est. Medicare Payment
National estimate based on 2026 CMS PFS Conversion Factor ($33.40). Actual payment varies by locality (GPCI adjustment).
Billing & Documentation
As a surgical CPT code, proper documentation must include the operative report detailing the procedure performed, patient positioning, approach, findings, and any complications. This code has a 0-day global period, meaning pre- and post-operative E&M visits are billable separately on the same day. Ensure the diagnosis code (ICD-10) supports medical necessity for the procedure.
How This Code Compares
With a work RVU of 4.46, this code ranks in the 30th percentile among Surgery codes — 1.8x below the median (8.00). The highest wRVU in this category is 106.19.
Specialties
Frequently Asked Questions
What is CPT code 45385?
CPT 45385 (Colonoscopy with lesion removal) is a Surgery code. Colonoscopy with removal of large polyp(s) requiring advanced polypectomy technique.
What is the wRVU value for CPT 45385?
The work RVU for CPT 45385 is 4.46. This code is primarily used by Colorectal Surgery, Gastroenterology, General Surgery.
When is CPT 45385 used?
Performed for large sessile polyps requiring piece-meal resection, endoscopic mucosal resection, or endoscopic submucosal dissection.
Track This Code in RVU Edge
Log procedures, calculate wRVUs, and benchmark against MGMA data — all in one app.
CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.