67221 Ocular photodynamic therapy
Also known as: photodynamic therapy, PDT, Visudyne, verteporfin therapy
Ocular photodynamic therapy involving intravenous injection of photosensitive dye followed by low-power laser activation to treat choroidal neovascular lesions without thermal damage.
In Plain Language
special light treatment of blood vessel membrane; dye and laser treatment of wet macular degeneration
Clinical Context
Used for pathologic myopia, polypoidal choroidal vasculopathy, and some choroidal neovascular lesions; requires strict light precautions post-treatment.
RVU Breakdown
| Work RVU | 3.36 |
| Total RVU | 3.36 |
Est. Medicare Payment
National estimate based on 2026 CMS PFS Conversion Factor ($33.40). Actual payment varies by locality (GPCI adjustment).
Billing & Documentation
As a surgical CPT code, proper documentation must include the operative report detailing the procedure performed, patient positioning, approach, findings, and any complications. This code has a 0-day global period, meaning pre- and post-operative E&M visits are billable separately on the same day. Ensure the diagnosis code (ICD-10) supports medical necessity for the procedure.
How This Code Compares
With a work RVU of 3.36, this code ranks in the 23rd percentile among Surgery codes — 2.4x below the median (8.00). The highest wRVU in this category is 106.19.
Specialties
Frequently Asked Questions
What is CPT code 67221?
CPT 67221 (Ocular photodynamic therapy) is a Surgery code. Ocular photodynamic therapy involving intravenous injection of photosensitive dye followed by low-power laser activation to treat choroidal neovascular lesions without thermal damage.
What is the wRVU value for CPT 67221?
The work RVU for CPT 67221 is 3.36. This code is primarily used by Ophthalmology, Retina.
When is CPT 67221 used?
Used for pathologic myopia, polypoidal choroidal vasculopathy, and some choroidal neovascular lesions; requires strict light precautions post-treatment.
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CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.