J0640 Leucovorin calcium injection
Also known as: leucovorin calcium, folinic acid, citrovorum factor
Leucovorin calcium (folinic acid) injection for intravenous or intramuscular administration, a reduced form of folic acid used as chemotherapy rescue agent.
In Plain Language
chemotherapy rescue medication; folate supplement injection
Clinical Context
Reduced folate cofactor administered after high-dose methotrexate to prevent myelosuppression and gastrointestinal toxicity. Also used to enhance fluorouracil efficacy in colorectal cancer.
RVU Information
CPT J0640 does not have a physician work RVU assigned by CMS. This is typical for supply, drug, and equipment codes — reimbursement is based on Average Sales Price (ASP), fee schedules, or payer contracts rather than the RVU system.
Billing & Documentation
J-codes represent drugs administered by a healthcare provider (not self-administered). Documentation must include the drug name, dosage, route of administration, and medical necessity. Most payers require the National Drug Code (NDC) on the claim. Bill the appropriate administration code (96365-96379) in addition to the drug code.
Specialties
Frequently Asked Questions
What is CPT code J0640?
CPT J0640 (Leucovorin calcium injection) is a J Codes (Drugs) code. Leucovorin calcium (folinic acid) injection for intravenous or intramuscular administration, a reduced form of folic acid used as chemotherapy rescue agent.
How is J0640 administered?
CPT J0640 is administered by a healthcare provider, typically via injection or infusion. Reduced folate cofactor administered after high-dose methotrexate to prevent myelosuppression and gastrointestinal toxicity. Also used to enhance fluorouracil efficacy in colorectal cancer. It is used by oncology, hematology, hospital medicine.
When is CPT J0640 used?
Reduced folate cofactor administered after high-dose methotrexate to prevent myelosuppression and gastrointestinal toxicity. Also used to enhance fluorouracil efficacy in colorectal cancer.
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CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.