81416 Exome sequence analysis
Also known as: exome sequencing with family, trio exome analysis
Whole exome sequence analysis for genetic disease evaluation with family member comparison or interpretation.
In Plain Language
gene test comparing families; comprehensive genetic analysis with relatives
Clinical Context
Exome sequencing with comparison to family members for disease gene identification; improves diagnostic accuracy.
RVU Information
CPT 81416 does not have a physician work RVU assigned by CMS. Reimbursement for this code is determined by payer-specific fee schedules.
Billing & Documentation
Lab and pathology codes require an order from the treating provider with clinical indication. For molecular pathology and genetic testing, document the specific analytes tested and clinical rationale.
How This Code Compares
This code has a work RVU of 0.00, meaning it does not have a physician work component assigned by CMS. In the Pathology & Lab category, 94% of codes share this characteristic.
Specialties
Frequently Asked Questions
What is CPT code 81416?
CPT 81416 (Exome sequence analysis) is a Pathology & Lab code. Whole exome sequence analysis for genetic disease evaluation with family member comparison or interpretation.
Who uses CPT code 81416?
CPT 81416 is used by genetics, molecular pathology, clinical genetics. Exome sequencing with comparison to family members for disease gene identification; improves diagnostic accuracy.
When is CPT 81416 used?
Exome sequencing with comparison to family members for disease gene identification; improves diagnostic accuracy.
Track This Code in RVU Edge
Log procedures, calculate wRVUs, and benchmark against national data — all in one app.
CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.