84165 Protein e-phoresis serum
Also known as: serum protein electrophoresis, SPEP, protein fractionation
Electrophoresis of serum proteins separating and quantifying albumin, alpha-1, alpha-2, beta, and gamma globulins.
In Plain Language
protein breakdown blood test
Clinical Context
Evaluates monoclonal proteins (multiple myeloma), immunoglobulin patterns, and protein composition; abnormal gamma spike suggests plasma cell disorder.
RVU Breakdown
| Work RVU | 0.37 |
| Total RVU | 0.37 |
Est. Medicare Payment
National estimate based on 2026 CMS PFS Conversion Factor ($33.40). Actual payment varies by locality (GPCI adjustment).
Billing & Documentation
Lab and pathology codes require an order from the treating provider with clinical indication. For molecular pathology and genetic testing, document the specific analytes tested and clinical rationale.
How This Code Compares
With a work RVU of 0.37, this code ranks in the 29th percentile among Pathology & Lab codes — 1.8x below the median (0.68). The highest wRVU in this category is 2.78.
Specialties
Frequently Asked Questions
What is CPT code 84165?
CPT 84165 (Protein e-phoresis serum) is a Pathology & Lab code. Electrophoresis of serum proteins separating and quantifying albumin, alpha-1, alpha-2, beta, and gamma globulins.
Who uses CPT code 84165?
CPT 84165 is used by Clinical Chemistry, Hematology, Laboratory Medicine. Evaluates monoclonal proteins (multiple myeloma), immunoglobulin patterns, and protein composition; abnormal gamma spike suggests plasma cell disorder.
When is CPT 84165 used?
Evaluates monoclonal proteins (multiple myeloma), immunoglobulin patterns, and protein composition; abnormal gamma spike suggests plasma cell disorder.
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CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.