86320 Serum immunoelectrophoresis
Also known as: SPEP, serum protein electrophoresis
Serum immunoelectrophoresis separates serum proteins by electric charge and identifies specific immunoglobulin classes, detecting immunoglobulin abnormalities and monoclonal proteins.
In Plain Language
Protein abnormality test; Myeloma screening
Clinical Context
Used to detect monoclonal proteins in multiple myeloma, light chain disease, and Waldenström macroglobulinemia. Identifies abnormal immunoglobulin peaks.
RVU Breakdown
| Work RVU | 0.37 |
| Total RVU | 0.37 |
Est. Medicare Payment
National estimate based on 2026 CMS PFS Conversion Factor ($33.40). Actual payment varies by locality (GPCI adjustment).
Billing & Documentation
Lab and pathology codes require an order from the treating provider with clinical indication. For molecular pathology and genetic testing, document the specific analytes tested and clinical rationale.
How This Code Compares
With a work RVU of 0.37, this code ranks in the 29th percentile among Pathology & Lab codes — 1.8x below the median (0.68). The highest wRVU in this category is 2.78.
Specialties
Frequently Asked Questions
What is CPT code 86320?
CPT 86320 (Serum immunoelectrophoresis) is a Pathology & Lab code. Serum immunoelectrophoresis separates serum proteins by electric charge and identifies specific immunoglobulin classes, detecting immunoglobulin abnormalities and monoclonal proteins.
Who uses CPT code 86320?
CPT 86320 is used by Hematology, Clinical Pathology, Hemato-Oncology. Used to detect monoclonal proteins in multiple myeloma, light chain disease, and Waldenström macroglobulinemia. Identifies abnormal immunoglobulin peaks.
When is CPT 86320 used?
Used to detect monoclonal proteins in multiple myeloma, light chain disease, and Waldenström macroglobulinemia. Identifies abnormal immunoglobulin peaks.
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CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.