81425 Genome sequence analysis
Also known as: whole genome sequencing, WGS, genome sequencing
Whole genome sequence analysis for genetic disease evaluation, proband analysis only.
In Plain Language
complete genetic blueprint test; full genome DNA sequencing
Clinical Context
Comprehensive sequence analysis of entire genome including noncoding regions; superior diagnostic yield for rare genetic diseases.
RVU Information
CPT 81425 does not have a physician work RVU assigned by CMS. Reimbursement for this code is determined by payer-specific fee schedules.
Billing & Documentation
Lab and pathology codes require an order from the treating provider with clinical indication. For molecular pathology and genetic testing, document the specific analytes tested and clinical rationale.
How This Code Compares
This code has a work RVU of 0.00, meaning it does not have a physician work component assigned by CMS. In the Pathology & Lab category, 94% of codes share this characteristic.
Specialties
Frequently Asked Questions
What is CPT code 81425?
CPT 81425 (Genome sequence analysis) is a Pathology & Lab code. Whole genome sequence analysis for genetic disease evaluation, proband analysis only.
Who uses CPT code 81425?
CPT 81425 is used by genetics, molecular pathology, clinical genetics. Comprehensive sequence analysis of entire genome including noncoding regions; superior diagnostic yield for rare genetic diseases.
When is CPT 81425 used?
Comprehensive sequence analysis of entire genome including noncoding regions; superior diagnostic yield for rare genetic diseases.
Track This Code in RVU Edge
Log procedures, calculate wRVUs, and benchmark against national data — all in one app.
CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.