45305 Proctosigmoidoscopy with biopsy
Also known as: proctoscopy with biopsy, sigmoidoscopy with biopsy, rectal biopsy
Proctosigmoidoscopy with tissue biopsy of rectum or sigmoid colon for histopathological evaluation.
In Plain Language
camera exam of rectum with tissue sample; rectal tissue sampling for testing
Clinical Context
Performed to evaluate suspicious lesions, inflammatory changes, persistent bleeding, chronic diarrhea, or abnormal findings requiring tissue diagnosis.
RVU Breakdown
| Work RVU | 1.12 |
| Total RVU | 1.12 |
Est. Medicare Payment
National estimate based on 2026 CMS PFS Conversion Factor ($33.40). Actual payment varies by locality (GPCI adjustment).
Billing & Documentation
As a surgical CPT code, proper documentation must include the operative report detailing the procedure performed, patient positioning, approach, findings, and any complications. This code has a 0-day global period, meaning pre- and post-operative E&M visits are billable separately on the same day. Ensure the diagnosis code (ICD-10) supports medical necessity for the procedure.
How This Code Compares
With a work RVU of 1.12, this code ranks in the 5th percentile among Surgery codes — 7.1x below the median (8.00). The highest wRVU in this category is 106.19.
Specialties
Frequently Asked Questions
What is CPT code 45305?
CPT 45305 (Proctosigmoidoscopy with biopsy) is a Surgery code. Proctosigmoidoscopy with tissue biopsy of rectum or sigmoid colon for histopathological evaluation.
What is the wRVU value for CPT 45305?
The work RVU for CPT 45305 is 1.12. This code is primarily used by Colorectal Surgery, Gastroenterology, Pathology.
When is CPT 45305 used?
Performed to evaluate suspicious lesions, inflammatory changes, persistent bleeding, chronic diarrhea, or abnormal findings requiring tissue diagnosis.
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CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.