45380 Colonoscopy and biopsy
Also known as: colonoscopy with biopsy, colon biopsy, colonoscopic biopsy, colonoscopy biopsy
Colonoscopy with tissue biopsy of colon for histopathological evaluation of lesions or inflammatory changes.
In Plain Language
tissue sample from colon; biopsy during colonoscopy
Clinical Context
Performed to obtain tissue diagnosis of suspicious lesions, inflammatory bowel disease, chronic diarrhea, or anemia of unclear etiology.
RVU Breakdown
| Work RVU | 3.47 |
| Total RVU | 3.47 |
Est. Medicare Payment
National estimate based on 2026 CMS PFS Conversion Factor ($33.40). Actual payment varies by locality (GPCI adjustment).
Billing & Documentation
As a surgical CPT code, proper documentation must include the operative report detailing the procedure performed, patient positioning, approach, findings, and any complications. This code has a 0-day global period, meaning pre- and post-operative E&M visits are billable separately on the same day. Ensure the diagnosis code (ICD-10) supports medical necessity for the procedure.
How This Code Compares
With a work RVU of 3.47, this code ranks in the 24th percentile among Surgery codes — 2.3x below the median (8.00). The highest wRVU in this category is 106.19.
Specialties
Frequently Asked Questions
What is CPT code 45380?
CPT 45380 (Colonoscopy and biopsy) is a Surgery code. Colonoscopy with tissue biopsy of colon for histopathological evaluation of lesions or inflammatory changes.
What is the wRVU value for CPT 45380?
The work RVU for CPT 45380 is 3.47. This code is primarily used by Colorectal Surgery, Gastroenterology, Pathology.
When is CPT 45380 used?
Performed to obtain tissue diagnosis of suspicious lesions, inflammatory bowel disease, chronic diarrhea, or anemia of unclear etiology.
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CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.