88364 Insitu hybridization (fish)
Also known as: in situ hybridization FISH, FISH single probe
Fluorescence in situ hybridization (FISH) analysis using probe(s) for single-color or single-probe detection in tissue.
In Plain Language
fluorescent gene probe test; colored genetic marker detection
Clinical Context
Molecular cytogenetic test using fluorescent probes to detect specific DNA sequences, chromosomal abnormalities, or gene amplifications.
RVU Breakdown
| Work RVU | 0.68 |
| Total RVU | 0.68 |
Est. Medicare Payment
National estimate based on 2026 CMS PFS Conversion Factor ($33.40). Actual payment varies by locality (GPCI adjustment).
Billing & Documentation
Lab and pathology codes require an order from the treating provider with clinical indication. For molecular pathology and genetic testing, document the specific analytes tested and clinical rationale.
How This Code Compares
With a work RVU of 0.68, this code ranks in the 53rd percentile among Pathology & Lab codes — 1.0x the median (0.68). The highest wRVU in this category is 2.78.
Specialties
Frequently Asked Questions
What is CPT code 88364?
CPT 88364 (Insitu hybridization (fish)) is a Pathology & Lab code. Fluorescence in situ hybridization (FISH) analysis using probe(s) for single-color or single-probe detection in tissue.
Who uses CPT code 88364?
CPT 88364 is used by Pathology, Molecular Pathology, Cytogenetics. Molecular cytogenetic test using fluorescent probes to detect specific DNA sequences, chromosomal abnormalities, or gene amplifications.
When is CPT 88364 used?
Molecular cytogenetic test using fluorescent probes to detect specific DNA sequences, chromosomal abnormalities, or gene amplifications.
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CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.