88368 Insitu hybridization manual
Also known as: in situ hybridization FISH manual, manual FISH
Fluorescence in situ hybridization (FISH) performed using manual microscopic analysis and interpretation for gene/chromosomal detection.
In Plain Language
hand-analyzed fluorescent gene probe test; manual genetic probe examination
Clinical Context
FISH analysis performed with manual microscopic interpretation for detection of chromosomal abnormalities and gene amplifications.
RVU Breakdown
| Work RVU | 0.86 |
| Total RVU | 0.86 |
Est. Medicare Payment
National estimate based on 2026 CMS PFS Conversion Factor ($33.40). Actual payment varies by locality (GPCI adjustment).
Billing & Documentation
Lab and pathology codes require an order from the treating provider with clinical indication. For molecular pathology and genetic testing, document the specific analytes tested and clinical rationale.
How This Code Compares
With a work RVU of 0.86, this code ranks in the 68th percentile among Pathology & Lab codes — 1.3x the median (0.68). The highest wRVU in this category is 2.78.
Specialties
Frequently Asked Questions
What is CPT code 88368?
CPT 88368 (Insitu hybridization manual) is a Pathology & Lab code. Fluorescence in situ hybridization (FISH) performed using manual microscopic analysis and interpretation for gene/chromosomal detection.
Who uses CPT code 88368?
CPT 88368 is used by Pathology, Molecular Pathology. FISH analysis performed with manual microscopic interpretation for detection of chromosomal abnormalities and gene amplifications.
When is CPT 88368 used?
FISH analysis performed with manual microscopic interpretation for detection of chromosomal abnormalities and gene amplifications.
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CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.