88366 Insitu hybridization (fish)
Also known as: in situ hybridization FISH multi-probe, FISH multi-color
Fluorescence in situ hybridization (FISH) analysis using three or more color probes or comprehensive probe panel for detection.
In Plain Language
multi-colored genetic probe test; chromosome panel analysis
Clinical Context
FISH using three or more fluorescent probes or comprehensive probe panels for detection of multiple chromosomal regions simultaneously.
RVU Breakdown
| Work RVU | 1.21 |
| Total RVU | 1.21 |
Est. Medicare Payment
National estimate based on 2026 CMS PFS Conversion Factor ($33.40). Actual payment varies by locality (GPCI adjustment).
Billing & Documentation
Lab and pathology codes require an order from the treating provider with clinical indication. For molecular pathology and genetic testing, document the specific analytes tested and clinical rationale.
How This Code Compares
With a work RVU of 1.21, this code ranks in the 85th percentile among Pathology & Lab codes — 1.8x the median (0.68). The highest wRVU in this category is 2.78.
Specialties
Frequently Asked Questions
What is CPT code 88366?
CPT 88366 (Insitu hybridization (fish)) is a Pathology & Lab code. Fluorescence in situ hybridization (FISH) analysis using three or more color probes or comprehensive probe panel for detection.
Who uses CPT code 88366?
CPT 88366 is used by Pathology, Molecular Pathology, Cytogenetics. FISH using three or more fluorescent probes or comprehensive probe panels for detection of multiple chromosomal regions simultaneously.
When is CPT 88366 used?
FISH using three or more fluorescent probes or comprehensive probe panels for detection of multiple chromosomal regions simultaneously.
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CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.