88365 Insitu hybridization (fish)
Also known as: in situ hybridization FISH dual probe, FISH two-color
Fluorescence in situ hybridization (FISH) analysis using two different color probes or multiple sequential probes for detection.
In Plain Language
two-colored genetic probe test; two-color chromosome analysis
Clinical Context
FISH using two different fluorescent probes for detection of two chromosomal regions or genes simultaneously.
RVU Breakdown
| Work RVU | 0.86 |
| Total RVU | 0.86 |
Est. Medicare Payment
National estimate based on 2026 CMS PFS Conversion Factor ($33.40). Actual payment varies by locality (GPCI adjustment).
Billing & Documentation
Lab and pathology codes require an order from the treating provider with clinical indication. For molecular pathology and genetic testing, document the specific analytes tested and clinical rationale.
How This Code Compares
With a work RVU of 0.86, this code ranks in the 68th percentile among Pathology & Lab codes — 1.3x the median (0.68). The highest wRVU in this category is 2.78.
Specialties
Frequently Asked Questions
What is CPT code 88365?
CPT 88365 (Insitu hybridization (fish)) is a Pathology & Lab code. Fluorescence in situ hybridization (FISH) analysis using two different color probes or multiple sequential probes for detection.
Who uses CPT code 88365?
CPT 88365 is used by Pathology, Molecular Pathology, Cytogenetics. FISH using two different fluorescent probes for detection of two chromosomal regions or genes simultaneously.
When is CPT 88365 used?
FISH using two different fluorescent probes for detection of two chromosomal regions or genes simultaneously.
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CPT® is a registered trademark of the American Medical Association. Data sourced from CMS Physician Fee Schedule RVU26A. Descriptions, synonyms, and clinical context are original content by RVU Edge.